Prediction of distant metastatic recurrence by tumor-infiltrating lymphocytes in hormone receptor-positive breast cancer

Abstract Background Breast cancer subtypes are known to have different metastatic recurrence sites. Distant metastases often observed during the post-operative course in patients with human epidermal growth factor receptor 2 (HER2)-enriched breast and triple-negative cancer, but relatively rare those hormone receptor-positive HER2-negative (HR+/HER2−) cancer. Tumor-infiltrating lymphocytes (TILs) serve as an index monitor tumor immune microenvironment may possibly predict prognosis therapeutic effect This study aimed investigate correlation between TIL density site HR+/HER2− Methods In stages I–II of who underwent surgery first treatment received adjuvant endocrine therapy (except chemotherapy), forty-two relapsed after surgery. TILs were evaluated using needle biopsy specimens for diagnosis Morphological assessment was conducted conventional hematoxylin eosin staining. Results Six had no density. them, local significantly less ( p = 0.022), while distant more 0.015) compared Therefore, prediction without chemotherapy, could be used predictors univariate analysis 0.015, odds ratio [OR] 0.127), although not independent factors 0.285, OR 0.144). Conclusions Our findings indicate that do undergo chemotherapy.